Madeleine: Key Events Timeline
Updated: 9:48am UK, Monday 14 October 2013
Here is a timeline of the key events since Madeleine McCann's disappearance.
:: May 3 - Kate and Gerry McCann leave their three children asleep in their holiday apartment in Praia da Luz while they dine with friends at a nearby tapas restaurant.
Jane Tanner, one of the friends eating with the McCanns, later reports seeing a man carrying a child away earlier that night.
:: May 5 - Portuguese police reveal they believe Madeleine was abducted but is still alive and in Portugal, and say they have a sketch of a suspect.
:: May 14 - Detectives take Anglo-Portuguese man Robert Murat in for questioning and make him an "arguido", or official suspect.
:: May 25 - Detectives release a description of the man reported by Jane Tanner three weeks earlier after pressure from the McCanns, their legal team and the British Government.
:: May 30 - Mr and Mrs McCann meet the Pope in Rome in the first of a series of trips around Europe and beyond to highlight the search for their daughter.
:: August 6 - A Portuguese newspaper reports that British sniffer dogs have found traces of blood on a wall in the McCanns' holiday apartment.
:: August 11 - Exactly 100 days after Madeleine disappeared, investigating officers publicly acknowledge for the first time that she could be dead.
:: September 7 - During further questioning of Mr and Mrs McCann, detectives make them both "arguidos" in their daughter's disappearance.
:: September 9 - The McCanns fly back to England with their two-year-old twins Sean and Amelie.
:: October 2 - Goncalo Amaral, the detective in charge of the inquiry, is removed from the case after criticising the British police in a Portuguese newspaper interview.
:: October 25 - The McCanns release a new artist's impression drawn by an FBI-trained expert showing the man described by Jane Tanner.
:: March 19 - Mr and Mrs McCann accept £550,000 libel damages and front-page apologies from Express Newspapers over allegations they were responsible for Madeleine's death.
:: April 7 - Three Portuguese detectives, led by Paulo Rebelo, fly to Britain to re-interview the seven friends on holiday with the McCanns when Madeleine vanished.
:: July 17 - Mr Murat receives £600,000 in libel damages from four newspaper groups over "seriously defamatory" articles connecting him with the child's disappearance.
:: July 21 - The Portuguese authorities shelve their investigation and lift the "arguido" status of the McCanns and Mr Murat.
:: August 4 - Thousands of pages of evidence from the Portuguese police files in the exhaustive investigation into Madeleine's disappearance are made public.
:: January 13 - Mr McCann returns to Portugal for the first time since coming back to the UK without his daughter.
:: March 24 - The McCanns launch a localised new appeal for information focused on the area in the Algarve where Madeleine disappeared.
:: April 4 - Mr McCann goes back to Portugal to help film a reconstruction of the events on the night his daughter vanished.
:: April 22 - The McCanns fly to the US to record an interview with chat show host Oprah Winfrey to mark two years since Madeleine's disappearance.
:: June 14 - Dying paedophile Raymond Hewlett says he was in the Algarve when Madeleine disappeared and has an alibi - but has no plans to reveal it.
:: August 6 - Detectives say they are hunting a "Victoria Beckham lookalike" with an Australian or New Zealand accent, reportedly seen in Barcelona three days after the little girl went missing.
:: Feb 18 - Kate and Gerry McCann say they are "pleased and relieved" at a judge's decision to uphold a ban on a book by former detective Goncalo Amaral.
:: Mar 3 - A newly-released file from Portugese police on possible sightings is called "gold dust" and could lead to a breakthrough, says a spokesman for the McCanns.
:: May 1 - Kate McCann reveals she had thoughts about being "wiped out" in a motorway crash to end the pain of losing Madeleine - but vows never to give up.
:: November 10 - Madeleine's parents launch an online petition to help force a UK and Portuguese joint review of all evidence in the case.
:: November 15 - The McCanns sign a deal to write a book about their daughter's disappearance.
:: May 13 - The Prime Minister David Cameron asks London's Metropolitan Police to help investigate the case.
:: November 23 - Kate and Gerry McCann appear at the Leveson Inquiry into media ethics.
They tell how media pressure affected their family life and accuse newspaper editors of hampering the search for their missing daughter.
Kate McCann says she felt "violated" when her diary was published without her permission.
:: December 5 - Scotland Yard detectives spend time in Barcelona as part of their re-examination of the case.
:: March 9 - Portuguese police in Oporto launch a review of the original investigation.
:: April 26 - Scotland Yard says Madeleine McCann may still be alive and release an artist's impression of what she may look like as a nine-year-old.
:: July 6 - British detectives examine a claim that the little girl's body is buried near the apartment from where she vanished. It comes after a self-styled investigator sends police radar scans he claims show a burial site.
:: Feb 11 - Gerry McCann calls for politicians to implement the conclusions of the Leveson Inquiry in full, backed by legislation.
:: Feb 13 - Police say the results of DNA tests on a girl in New Zealand who was mistaken for Madeleine reveal that she is not the missing British girl.
:: Feb 21 - Retired solicitor Tony Bennett who published claims that Madeleine McCann's parents caused her death is given a suspended jail sentence.
:: May 2 - Madeleine McCann's parents tell Sky News a police review into their daughter's disappearance is making "excellent progress" as they mark the sixth anniversary since she went missing.
:: May 17 - Scotland Yard say they have identified a number of "people of interest" they want to speak to. It believes it has found enough evidence to reopen the case but the Portuguese authorities are still resistant.
:: June 15 - The Home Office agrees to fund a full-scale investigation by the Metropolitan Police.
:: October 13 - UK detectives reviewing the case say key details in the timeline of her disappearance have "significantly changed".
:: October 14 - A fresh appeal is launched in a bid to find a suspect detectives say is of "vital importance", with two new separate e-fits - thought to be of the same man seen on the night Madeleine went missing - released by police.