The mission in Afghanistan is moving into its "final phases", David Cameron has said, at a joint press conference with US President Barack Obama.
Speaking at the White House, both leaders stressed that progress had been made in the country - despite losses of US, British and Afghan lives.
International forces will take on a support role from 2013, Afghans will fully take over security in 2014.
The PM said they would not "give up on this mission", despite its "high cost".
Tensions are high in Afghanistan after an American soldier shot dead 16 Afghan civilians.
On Wednesday a truck was reportedly driven onto the runway at Camp Bastion, the main British military base in Afghanistan, and burst into flames.
'Real progress'Speaking after talks with Mr Cameron at the White House, the US president said the tragic events of recent days was a reminder of how difficult the mission was.
But he said: "What we can never forget is our forces are making very real progress."
"Start Quote
End Quote US President Barack ObamaWe are going to complete this mission and we are going to do it responsibly."
Mr Obama said troops were making headway against the Taliban and al Qaeda and were training Afghan forces.
He said details of the next stage of transition to Afghan control would be set out at the upcoming Nato summit in Chicago but added: "This includes shifting to a support role next year in 2013 in advance of Afghans taking full responsibility for security in 2014.
"We are going to complete this mission and we are going to do it responsibly."
'Not perfect'Mr Cameron is on a three-day trip to the US and was earlier welcomed to Washington with a 19-gun salute on the South Lawn of the White House.
He said: "We will not give up on this mission because Afghanistan must never again be a safe haven for al Qaeda to launch attacks against us.
"Start Quote
End Quote David Cameron on SyriaWe must do everything we can to achieve a political transition that will stop the killing"
"We will not build a perfect Afghanistan, although let's be clear, we are making some tangible progress.
"But we can help ensure that Afghan is capable of delivering its own security without the need for large numbers of foreign troops."
He added: "We are now in the final phases of our military mission.
"That transition to Afghan control, as agreed at Lisbon, is now well under way. And next year, as the president said, in 2013, this includes shifting to a support role."
And he added that he would work with Afghan President Hamid Karzai for a "politically led solution".
British and US combat troops are expected to leave Afghanistan completely by the end of 2014.
The two leaders also discussed Syria, Iran and economic growth.
The United Nations has suggested more than 8,000 people have died since anti-government protests erupted in Syria a year ago, with many casualties in Homs where government forces have been trying to root out rebel fighters.
Mr Cameron said Britain was pledging an additional £2m for food and medical care, adding: "We must do everything we can to achieve a political transition that will stop the killing."
The president and prime minister were in the front row at the US college basketball championships
Earlier he was greeted by Mr Obama and his wife Michelle, as well as US Secretary of State Hillary Clinton and Vice President Joe Biden, on his arrival in Washington.
In remarks ahead of talks, they stressed the strength of the "rock solid" relationship between the UK and US, which Mr Obama said was the "strongest it's ever been".
The White House talks was followed by lunch attended by UK Chancellor George Osborne, Foreign Secretary William Hague, Vice President Biden and Mrs Clinton.
Together with his wife Samantha, Mr Cameron is later expected to visit a school for children with disabilities. A state dinner will round off the day.
The guest list includes UK stars including Homeland actor Damian Lewis and Northern Irish golfer Rory McIlroy, with entertainment provided by British folk group Mumford and Sons and US R&B star John Legend.
Mr Cameron made his first official visit to the US as prime minister in July 2010. The latest meeting comes ahead of Nato and G8 summits.
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