He likened the sufferings of the citizens of Misurata to those of a "medieval siege" which threatened to "strangle its population into submission".
The joint pledge came as Nato admitted that the refusal of Italy, Spain and Holland to allow their combat planes to carry out ground strikes is causing the alliance to lose momentum in attacks on Col Gaddafi's forces.
Mr Obama has faced criticism in recent days for pulling the US back from an initially aggressive role in Libya.
The article, which was jointly published in the Times, Le Figaro and the Washington Post, said Col Gaddafi must "go and go for good", and continued: "Gaddafi has promised to carry out terrorist attacks against civilian ships and airliners.
"And because he has lost the consent of his people any deal that leaves him in power would lead to further chaos and lawlessness.
"We know from bitter experience what that would mean. Neither Europe, the region nor the world can afford a new safe haven for extremists."
Mr Obama, Mr Cameron and Mr Sarkozy promised that the international coalition against Col Gaddafi would continue its military operations in Libya, saying: "So long as Gaddafi is in power, Nato and its coalition partners must maintain their operations so that civilians remain protected and the pressure on the regime builds.
"Britain, France and the United States will not rest until the United Nations Security Council resolutions have been implemented and the Libyan people can choose their own future."
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