By Philip Duncan Last updated at 3:43 PM on 30th January 2011

Samir Nasri is set to miss the first leg of Arsenal's Champions League tie against Barcelona with a hamstring injury.

The star midfielder pulled up clutching the top of his left leg after 32 minutes of the 2-1 victory over Huddersfield in the FA Cup, and was immediately replaced by Tomas Rosicky.

Down and out: an injured Nasri winces after pulling up in the first half

Down and out: an injured Nasri winces after pulling up in the first half

Arsene Wenger revealed after the game that he wanted to rest the in-form Frenchman, but was forced to start with him from the beginning after Rosicky failed to recover from illness.

Agony: Nasri grabs his left hamstring

Agony: Nasri grabs his left hamstring

'Nasri looks to have a serious hamstring injury,' Wenger said. 'Usually it is three weeks, we have to see if it a Grade One because that can be two [weeks].

'I have regrets, because the plan was first to play Rosicky but he was still too weak because he was sick.

'So I took the gamble on Nasri and it back-fired but he could have come on and because it was after 25 or 30 minutes it could have happened as well if he comes on.

'It is difficult to predict but of course we are at the stage of the season that we play so many games that to lose bodies is very difficult for us.

'It is a big blow, how big I do not know because the results in the future will tell, but it is a big blow. 'Put three weeks to today's game and you will know [if he misses the Barcelona game]. I think yes'